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Contributions of Resin Cast Etching to Visualising the Osteocyte Lacuno-Canalicular Network Architecture in Bone Biology and Tissue Engineering

The osteocyte lacuno-canalicular network is a fundamental structural and functional component of bone. The osteocytes play the vital role of mechanosensory cells by orchestrating bone remodeling. Furthermore, the morphology of the osteocyte lacuno-canalicular network (e.g., osteocyte interconnectivity) reflects the underlying mechanobiological status of bone, which is relevant for understanding the processes of bone growth and … Read more

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Improving musculoskeletal health worldwide, together. Learn more Join us live on November 16! X-Linked Hypophosphatemia (XLH): Comprehensive Strategies for Early Diagnosis and Lifelong Management in Children and Adults Register for webinar Improving musculoskeletal health worldwide, together. Learn more Join us live on November 16! X-Linked Hypophosphatemia (XLH): Comprehensive Strategies for Early Diagnosis and Lifelong Management … Read more

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Membership Join us as we work collaboratively across the field of MSK to support excellence in science, research, and clinical care. Contact us FULL MEMBERSHIP Our members are organizations with a focus on MSK research, education, or clinical care.Membership benefits: Share your society’s achievements and activities with our members to showcase your work and successes … Read more

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Resources Libraries of MSK resources, developed by experts Stay updated on MSK news RESOURCES Musculoskeletal Knowledge Portal A genomic data mining platform aimed at accelerating discoveries for musculoskeletal traits and diseases (partnership with the MIT Broad Institute/Harvard University) Explore MSK-KP XLH Information Hub Providing health care professionals with the essential tools to identify, diagnose, and … Read more

Building the Virtual Human Twin: Latest in Skeletal Digital Twins

https://www.youtube.com/watch?v=8BpZrbmYhQY& Recording of the 2025 ECTS–IFMRS Joint Session, ViennaSpeaker: Prof. Liesbet Geris (University of Liège & KU Leuven, Belgium) Digital twins are no longer just an engineering curiosity; they are becoming a cornerstone of personalized medicine. In this keynote, delivered at the 2025 ECTS–IFMRS meeting in Vienna, Prof. Liesbet Geris demonstrates how patient-specific models are … Read more

Digital Twins Power Early Diagnosis & Targeted Therapy

https://www.youtube.com/watch?v=UXmOHDGmirI& Recording of the 2025 ECTS–IFMRS Joint Session, ViennaSpeaker: Dr Xinxiu Li (Karolinska Institutet, Stockholm, Sweden) Digital-twin technology can do more than replicate organs; it can clone entire patients in silico. In this talk, Dr Lin Xinxiu shows how multi-omic, single-cell, and spatial data feed high-resolution “copies” of arthritis sufferers, letting researchers trial thousands of … Read more

Autoantibody mediated inflammation co-activates FcgR and IFNgR pathways in osteoclasts

Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts Bone remodeling is a continuous and uninterrupted process in which old bone tissue is removed by osteoclasts (the bone-resorbing cells) while, in parallel, new bone substance is formed by osteoblasts (the bone-building cells). Normal osteoclast activity is essential for the … Read more