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Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis

Abstract The pericellular matrix (PCM) of cartilage is a structurally distinctive microdomain surrounding each chondrocyte, and is pivotal to cell homeostasis and cell-matrix interactions in healthy tissue. This study queried if the PCM is the initiation point for disease or a casualty of more widespread matrix degen- eration. To address this question, we queried the … Read more

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Membership Join us as we work collaboratively across the field of MSK to support excellence in science, research, and clinical care. Contact us FULL MEMBERSHIP Our members are organizations with a focus on MSK research, education, or clinical care.Membership benefits: Share your society’s achievements and activities with our members to showcase your work and successes … Read more

News & Events

News & Events MSK news, articles and events, all in one place.  Stay updated on MSK news IFMRS NEWS & EVENTS UPCOMING X-Linked Hypophosphatemia (XLH): Comprehensive Strategies for Early Diagnosis and Lifelong Management in Adults Learn more SEP 2026 New Look, New Hub, New Publication: What’s Happening at IFMRS Read more JUL 2026 New Three-Year Strategy and … Read more

Building the Virtual Human Twin: Latest in Skeletal Digital Twins

https://www.youtube.com/watch?v=8BpZrbmYhQY& Recording of the 2025 ECTS–IFMRS Joint Session, ViennaSpeaker: Prof. Liesbet Geris (University of Liège & KU Leuven, Belgium) Digital twins are no longer just an engineering curiosity; they are becoming a cornerstone of personalized medicine. In this keynote, delivered at the 2025 ECTS–IFMRS meeting in Vienna, Prof. Liesbet Geris demonstrates how patient-specific models are … Read more

Digital Twins Power Early Diagnosis & Targeted Therapy

https://www.youtube.com/watch?v=UXmOHDGmirI& Recording of the 2025 ECTS–IFMRS Joint Session, ViennaSpeaker: Dr Xinxiu Li (Karolinska Institutet, Stockholm, Sweden) Digital-twin technology can do more than replicate organs; it can clone entire patients in silico. In this talk, Dr Lin Xinxiu shows how multi-omic, single-cell, and spatial data feed high-resolution “copies” of arthritis sufferers, letting researchers trial thousands of … Read more

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ADVANCING MUSCULOSKELETAL RESEARCH GLOBALLY Read More The IFMRS is an international, not-for-profit federation of musculoskeletal research societies. Our purpose is to promote excellence in the field of musculoskeletal science, in order to improve the prevention and treatment of all musculoskeletal conditions worldwide. We do this by collaborating with, and fostering collaboration between, local, regional and international societies to share … Read more