MSK NEWS

Osteoporosis fractures fall by 94% in small first-in-human stem cell trial

A recent study published in Cell explored a novel stem cell therapy for advanced osteoporosis that cleverly uses a patient's own stem cells as a biological targeting tag, binding to blood vessels in the bone marrow and guiding the infused stem cells directly to damaged bone tissue.

In a first-in-human trial, 10 women over 50 with advanced osteoporosis received an infusion of the specially engineered repair cells via a single intravenous (IV) drip.

In the first two years after treatment, fractures caused by weakened bones fell by 94%, from eight fractures per year to 0.5 fractures per year, across the group. Post-treatment bone biopsies showed that the mean bone tissue area nearly doubled in just four months. Most patients also reported less pain after receiving the infusion, with a 34% reduction at month 24.

Read the full article below!