• Big Data Inventory

    The International Federation of Musculoskeletal Research Societies (IFMRS) established the IFMRS Big Data Work Group in 2013 to assist members in accessing and utilizing existing databases for musculoskeletal research.

    The means to accomplish this goal include the following:

    1. Provide an online list of websites and how to access them.
    2. Assimilate a list of databases categorized according to disease, tissue, cells, mouse models, patient and population data.
    3. Identify educational opportunities and training for members.
    4. Identify ways to promote collaboration.
    5. Identify potential support and funding for collaborative projects.

    As a first step, an inventory of websites has been generated to assist members in accessing and utilizing existing databases for musculoskeletal research. The IFMRS Big Data Website Inventory is divided into the following four categories:

    This inventory will continue to be modified with new information on a regular basis.

    The next step in the project will be to assimilate a list of databases categorized according to disease, tissue, cells, mouse models, and patient and population data. Categories may include basic research databases such as cell lines, translational research data bases such as animal models, and clinical research data bases to include GWAS for diseases such as osteoporosis, sarcopenia and osteoarthritis.

    As an initial effort to provide education and training for members, a session was conducted during the ASBMR 2014 Annual Meeting in Houston, Texas on how the ENCODE Project can support musculoskeletal research. Dr. Elise Feingold, Project Director from the US National Human Genome Research Institute (NHGRI) and Dr. Timothy Hubbard, Professor of Bioinformatics at Kings College in London.  Dr. Feingold spoke on the resources that ENCODE provides and Dr. Hubbard spoke on how musculoskeletal research could benefit from ENCODE resources. During the ASBMR 2015 Annual Meeting in Seattle, Washington, additional sessions on Big Data were conducted. The IFMRS Work Group sponsored a session called "Small Ways to Utilize Big Data in your Research." Dr. Matthew Brown spoke on utilizing big data to translate genetic into clinical practice, and Dr. Matthew Maurano spoke on using the newest version of RoadMap and ENCODE data in genomic research. Additionally, there was a Molecular Biology and Pathology of the Skeleton Working Group Session.

    NOTE: The Encyclopedia of DNA Elements (ENCODE) Consortium is an international collaboration of research groups funded by the National Human Genome Research Institute (NHGRI). The goal of ENCODE is to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active.

    Members of the IFMRS Big Data Work Group

    • Lynda F. Bonewald, Ph.D., Chair
      American Society for Bone and Mineral Research (ASBMR)
    • José Luis Aguilar Olano, M.D.
      Ibero American Society of Osteology and Mineral Metabolism (SIBOMM)
    • Emma Duncan, M.D., Ph.D.
      Australia and New Zealand Bone and Mineral Society (ANZBMS) 
    • Shiro Ikegawa, M.D., Ph.D.
      Japanese Society of Bone and Mineral Research (JSBMR)
    • Yuuki Imai, M.D., Ph.D.
      Japanese Society of Bone and Mineral Research (JSBMR)
    • David Karasik, Ph.D.
      International Bone and Mineral Society (IBMS)
    • Douglas P. Kiel, M.D., MPH
      American Society for Bone and Mineral Research (ASBMR)
    • Jian Li, Ph.D.
      International Chinese Musculoskeletal Research Society (ICMRS)
    • Jane Lian, Ph.D.
      American Society for Bone and Mineral Research (ASBMR)
    • Craig Munns, MBBS, Ph.D., FRACP
      Australia and New Zealand Bone and Mineral Society (ANZBMS) 
    • Tomoki Nakashima, M.D., Ph.D.
      Japanese Society of Bone and Mineral Research (JSBMR)
    • Konstantino Tserotas, M.D.
      Ibero American Society of Osteology and Mineral Metabolism (SIBOMM)
    • Wesley Pike, Ph.D.
      American Society for Bone and Mineral Research (ASBMR)
    • Fernando Rivadeneira, M.D., Ph.D.
      European Calcified Tissue Society (ECTS)  
    • Tim Spector, M.D.
      European Calcified Tissue Society (ECTS)   
    • Gary Stein, Ph.D.
      American Society for Bone and Mineral Research (ASBMR)
    • Yoshiya Tanaka, M.D., Ph.D.
      Japanese Society of Bone and Mineral Research (JSBMR)
    • Jennifer Westendorf, Ph.D.
      Orthopaedic Research Society (ORS)